I tend to use a combination of Photoshop and SAI for my drawings. SAI is more comfortable for me to use, but Photoshop has access to a lot of features that SAI lacks, so I tend to combine both of them.
I know lots of people who draw in SAI and use Photoshop to edit their work after.
I tend to use Photoshop more, but I think I prefer the brush effects of SAI. Things tend to blend better.
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