I'll add my two cents on the topics of violence, sexual themes and profanity. In my own PMD story, all are present, none of these topics bother me on their own. What does bother me is when they are used simple for the sake of having them. If something makes someone uncomfortable it's not necessarily a bad thing as long as it is adding something to the overall story. Unfortunately these themes tend to get a bit out of hand so keeping them to a restricted minimum is probably best for all.